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KMID : 0941819980080020139
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Korean Journal of Clinical Pharmacy
1998 Volume.8 No. 2 p.139 ~ p.142
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Effects of Herbal Medicines on Monoamine Oxidase Activity
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Byun Jae-Won
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Abstract
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The effects of MeOH extracts from 28 herbal medicines on monoamine oxidase (MAO) activity were investigated. MAO was purified from mouse brain and its activity was determined by fluoro-photometry using kynuramine as a substrate. Three MeOH extracts, Coptis japonica, Cinnamomum cassia and Poncirus trifoliate from the herbal medicines showed a strong inhibitory effect with less than 100;{mu}g/ml in their inhibitory amounts of 50% (IC_{50} values) on MAO activity. Four MeOH extracts including Evodia officinalis exhibited a mild inhibition of MAO activity with 100-200;{mu}g/ml in their IC_{50} values.
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KEYWORD
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